Xenia Ghali on House Party Radio

After earning her bachelor's degree, Ghali enrolled in the Film Scoring, Music Composition and Production Master's program at New York University. While in New York, she competed in the 2013 iStandard Producer Showcase in New York City and was one of two winners. During the summer of 2013 she worked extensively in her home country Greece, performing at a number of live events including the 2013 MAD Video Music Awards Kick Off Party, the 2013 MAD Video Music Awards, and the 2013 Str8 Forward Festival.

Ghali founded Funky Sheep Records in 2013.

In May 2014 Ghali co-wrote and produced Ben Moon's "Change", which was also remixed by Jose Nunez.

In August 2014 she signed with Pitbull's record label Mr 305 and released her debut single "Broken" with Katt Rockell; the track hit Top 30 on US Dance radio. The track was released with a fashion-oriented video. Ghali released a slightly different version of "Broken" in Greek with Tamta titled "Gennithika Gia Sena". It was released in 2014 by Minos EMI. "Gennithika Gia Sena" peaked at number 2 on Greek radio. She performed it at the 2014 MADwalk - Fashion Music Project.

In summer of 2014 she collaborated with Greek Pop star Sakis Rouvas and co-wrote and produced his single "Open Eyes" which he performed at the World Music Awards. "Open Eyes" was also released in Greek titled "Pio Psila". Ghali also remixed a number of tracks on Mr 305, such as Pitbull's "Fun", which featured Chris Brown and for Mr Vegas' "My Jam", which featured Pitbull.

Later in 2014 Ghali spent time working in the US and performed with Erick Morillo on Hollywood Hamilton's 'Remix Top 30'. Wyclef Jean made a guest appearance during her set and performed their single "Get Dirty". The two also performed "Get Dirty" at the 2015 SXSW in Austin, Texas; Ghali operated the turntables and played the piano. The track was released in 2015 on her label Funky Sheep Records.

Ghali presented an award to Hardwell at the 2015 Winter Music Conference IDMAs in Miami Florida. In 2016, Ghali released "Under These Lights" through her label Funky Sheep Records. On 18 June 2016, the single reached number 1 on the US Billboard Dance Club Songs chart. The chart position resulted in an interview with Billboard, as well as interviews with The Huffington Post and AOL.

Ghali also performed "Under These Lights" on Greece's X Factor and is a brand ambassador for G-Star Raw, Adidas and Eastpak in Greece. Ghali's single, "Places", was released at the end of 2016 and features vocals from singer-songwriter and actress Raquel Castro. The song also has a music video starring Teen Wolf star Ryan Kelley. "Places" earned Ghali her second number 1 Billboard Dance Club Song Chart position.

On January 26, 2018 Ghali released her single "Stick Around" with EDX's label Sirup Music. Regarding the story behind the release on Syrup Music, the female artist revealed the following: "EDX was actually one of the DJs who received the song. I found out he played it at one of his shows in San Francisco and I reached out to thank him for the support. Then to my surprise he told me that he was interested in releasing it under Sirup Music (his label) and of course I agreed!"

On September 27, 2019, Xenia Ghali's beat from "Black Betty's Worldwide" was used as a sample in "Get Ready" by Pitbull featuring Blake Shelton. The song released as a single on January 30, 2020, and the music video premiered on Pitbull's YouTube channel on February 10, 2020. Ghali received producer credit for her contribution of the instrumental to the song.

Ghali has DJed at a few of the world's most notable clubs including the Ministry of Sound, Cavo Paradiso, Cielo and Nikki Beach and has played alongside DJs including Steve Aoki, Erick Morillo, Martin Solveig, Don Diablo, Dubvision, Cedric Gervais and Jay Hardway. She has also headlined festivals including the Colour Day Festival, Lindos Summer Paradise and Angel's Cafe Summer Paradise.